Scientific Research

Purified anthocyanin supplementation improves endothelial function via NO-CGMP activation in hypercholesterolemic individuals

Synopsis:

  • Anthocyanin supplemented adults observed significant increases of flow-mediated dilation by  11% after short-term consumption
  • Participants who received long-term anthocyanin intervention, compared to the control group, observed increases in flow-mediated dilation of 28.4% (vs 2.2% in placebo group)
  • Participants observed increases in HDL-cholesterol concentrations and decreases in LDL cholesterol concentrations
  • Anthocyanin supplementation improved endothelium-dependent vasodilation in hypercholesterolemic individuals

Clinical Chemistry: 11524-33 (2011)

The ability of blackcurrant extracts to positively modulate key markers of gastrointestinal function in rats

Synopsis

  • NZ blackcurrant extract promoted the growth of lactobacilli and bifidobacterial in the caccum of rats, which reduced the formation of harmful carcinogens in the intestine
  • NZ blackcurrant extract confirmed as good prebiotic agents that can significantly promote the growth of friendly bacteria and lower the numbers of undesirable bacteria
Protective effects of berry polyphenols against age-related cognitive impairment

Synopsis:

  • Dietary polyphenols can modulate brain health and function
  • Berry fruit compounds, through their antioxidant activity, their effect on brain signaling functions and inhibition of neuroinflammation have a global effect on brain cell integrity
  • Berry polyphenols are essential micronutrients for improving cognitive function

Nutrition and Ageing 3 89-106 (2015)

The neuroprotective potential of flavonoids: A multiplicity of effects

Synopsis:

  • Flavonoids offer neuroprotective actions within the brain
  • They have the potential to protect neurons against injury induced by neurotoxins
  • They have the ability to suppress neuroinflammation, which is believed to play a crucial role in the development of neurodegenerative diseases 
  • Strong evidence that flavonoids promote memory, learning and cognitive function
  • Flavonoids interact to inhibit cell death triggered by neurotoxic species and to promote neuronal integrity 
  • They induce beneficial effects on the vascular system and improve blood flow to the brain
  • Flavonoid-rich food hold the potential to limit neurodegeneration and to prevent or reverse age-dependent losses in cognitive performance

Genes Nutrition, 3:115-126 (2008)

Effects of anthocyanins and other phenolics of boysenberry and blackcurrant as inhibitors of oxidative stress and damage to cellular DNA in SH-SY5Y and HL-60 cells

Synopsis: 

  • Anthocyanins and phenolics from blackcurrant were better at protecting DNA of HL-6- human promyelocytic cells from damage than from boysenberry
  • Blackcurrant extract demonstrated the highest protective effect against H2O2-induced neurotoxicity, oxidative stress and DNA damage
  • Anthocyanins reduce oxidative stress and ultimately the risk of developing certain chronic and degenerative diseases

Journal of the Science of Food and Agriculture: 86:678-868 (2016)

Lowering of oxidative stress improves endothelial function in healthy subjects with habitually low intake of fruit and vegetables: A randomized controlled trial of antioxidant and polyphenol-rich blackcurrant juice

Synopsis:

  • Double-blind, placebo-controlled,  parallel group study of 66 healthy adults who habitually consume less than two portions of fruit and vegetables per day. 
  • Participants consumed either placebo (flavoured water) or blackcurrant juice four times a day for six weeks. 
  • Blackcurrant juice group observed increased flow mediated dilation (blood flow)
  • Blackcurrant group observed reduced oxidative stress and improved vascular health

Published Free Radical Biology and Medicine, 2013

Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol

Synopsis:

  • 24 mice with diet-induced severe fatty liver, hypercholesterolaemia (high choleseterol) and hyperglycaemia 
  • Total plasma cholesterol and glucose levels were significantly lower in blackurrant group
  • Blackcurrant group had significantly decreased LDL
Acute supplementation with blackcurrant extracts modulate cognitive functioning and inhibits monoamine oxidase-B ini healthy young adults

Synopsis: 

  • 35 young adults asked to complete 70-minute computerized assessments designed to demand constant attention and create mental fatigue
  • Participants supplemented with blackcurrant completed work more accurately without slowing down
  • Blackcurrant participants observed less perceived effort and felt more alert after the test
  • Group on blackcurrant observed an inhibition of enzymes associated with Parkinson’s disease to clinically significant  degree (Monoamine oxidase-B and Monoamine  Oxidase-A). 

Journal of Functional Foods, 2015 (524-539)

Blackcurrant anthoycanins Attenuate Weight Gain and Improve Glucoses Metabolism in Diet-Induced Obese Mice with Intact, but not Disrupted, Gut Microbiome
  • Mice on low or high-fat diets were supplemented with powdered blackcurrant extract (32% anthocyanins)  for eight weeks
  • Mice with intact gut microbiomes fed high-fat diets and supplemented with blackcurrant resulted in 8-10% less weight gain, compared to control group
  • Anthocyanin biotransformation more active in animals with intact gut microbiome

Published, Journal of Agricultural and Food Chemistry, June 2015

Anti-influenza virus activity of two extracts of the Blackcurrant from New Zealand and Poland

Synopsis:

  • New Zealand blackcurrant extract showed anti-viral effects against all four strains of influenza virus (IFV) tested
  • Anthocyanins from NZ blackcurrant extract inhibit influenza virus adsorption to cells and virus release from infected cells
  • Blackcurrant had an anti-septic effect against multiple strains of IFV as a prevention against infection
  • New Zealand blackcurrant showed ‘definite’ potential for use as a disinfectant and antiseptic agent to prevent IFV infection
Vasodilation Peripheral
Muscle Trial

Synopsis

  • Increases resting blood flow
  • Prevents decrease in muscle oxygenation that occurs during exercise
  • Increases production nitric oxide
  • Increases arterial flow to muscle tissue
  • Reduces workload on muscles due to increase blood flow and oxygen supply
  • Facilitates removal of unfavorable metabolites (lactic acid, free fatty acids, etc)
  • Prevents hypoxia and disturbance of oxidative metabolism in muscles
Polyphenolic phytochemicals – just antioxidants or much more?

Synopsis

  • Protects cells from oxidative stress, which leads to intracellular imbalanced DNA lesions (thus inhibiting DNA damage)
  • Polyphenols reduce oxidative stress by antioxidant enzymes
  • Polyphenols act as inflammatory modulatory agents by inhibiting the inflammatory signalling cascades
  • Increases the cells' ability to scavenge ROS* produced in inflammatory processes.